Lower extremity erythema and tightening in an elderly male

A 71-year-old man presented with lower extremity erythema and skin thickening. His medical history included metastatic prostate cancer treated with docetaxel, complicated by treatment-limiting lower extremity edema. He had previously undergone gadolinium-contrasted magnetic resonance imaging and remotely used L-tryptophan. One month after chemotherapy, progressive painful lower extremity tightening and erythema had developed. He denied dysphagia, Raynaud phenomenon symptoms, myalgias, weakness, or renal dysfunction.

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