A history of the DNA repair and mutagenesis field

Publication date: January 2016
Source:DNA Repair, Volume 37
Author(s): Errol C. Friedberg
This article reviews the early history of the discovery of an DNA repair pathway designated as base excision repair (BER), since in contrast to the enzyme-catalyzed removal of damaged bases from DNA as nucleotides [called nucleotide excision repair (NER)], BER involves the removal of damaged or inappropriate bases, such as the presence of uracil instead of thymine, from DNA as free bases.



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