Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke

Thrombolytic therapy with intravenous alteplase (recombinant tissue-type plasminogen activator) at a dose of 0.9 mg per kilogram of body weight is an effective treatment for acute ischemic stroke, despite increasing the risk of intracerebral hemorrhage. However, the Japanese drug safety authority…

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