Anchored protein folding [Biological Sciences]

In a recent article in PNAS, Zhuravlev et al. (1) determine unfolding trajectories of the Src tyrosine kinase SH3 (Src homology 3) domain [Protein Data Base (PDB) ID code 1SRL]. Using laser optical tweezing, constant force was applied to the SH3 N and C termini (residues 9 and 59), and...

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