Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses [Immunology and Inflammation]

Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental allergens and protecting against allergic diseases. Still, the precise molecular cues that underlie their transcriptional and functional specification remain elusive. Here, we show that the cytokine activin-A instructs the generation of CD4+ T...

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