Intracellular metabolite {beta}-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity [Immunology and Inflammation]

Sensing and reacting to tissue damage is a fundamental function of immune systems. Macrophage inducible C-type lectin (Mincle) is an activating C-type lectin receptor that senses damaged cells. Notably, Mincle also recognizes glycolipid ligands on pathogens. To elucidate endogenous glycolipids ligands derived from damaged cells, we fractionated supernatants from damaged...

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