Can we effectively use radiographic imaging and clinical parameters for making an earlier diagnosis of granulomatous interstitial lung disease in patients with common variable immunodeficiency?

Noninfectious complications in patients with common variable immunodeficiency (CVID) are increasingly being recognized as major sources of morbidity and mortality.1 Chronic pulmonary disease directly due to infections, possibly as a consequence of delayed or under treatment with replacement immunoglobulin (Ig), has been well recognized as a cause of significant problems in patients with CVID but has decreased with appropriate replacement immunoglobulin therapy.2,3 Although the underlying causes of noninfectious complications of the pulmonary system for most remain unknown, autoimmunity and postinfectious inflammatory reactions could be responsible, and these are surpassing infections as causes of morbidity and mortality.

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