Fast folding and slow unfolding of a resurrected Precambrian protein [Biological Sciences]

Tzul et al. (1) report different unfolding rates and similar folding rates for a number of thioredoxins. The authors interpret this result as evidence of the principle of minimal frustration. Their study includes several resurrected Precambrian thioredoxins that we have previously prepared and characterized (2–5). We agree that the principle...

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