NIS in pure TFA is a time-efficient and general method for the iodination of a wide range of mono- and disubstituted benzenes at room temperature as demonstrated in this paper. The starting materials were generally converted into mono-iodinated products in less than 16 hours at room temperature, without by-products. A few deactivated substrates needed addition of sulphuric acid to increase reaction rate. Another exception was methoxybenzenes that preferentially were iodinated by NIS in acetonitrile with only catalytic amounts of TFA.
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