Δευτέρα 12 Ιουνίου 2017

Dissecting mechanism of coupled folding and binding of an intrinsically disordered protein by chemical synthesis of conformationally constrained analogues

GA?id=C7CC02276J

Chem. Commun., 2017, Advance Article
DOI: 10.1039/C7CC02276J, Communication
Boris Schmidtgall, Olivier Chaloin, Valentin Bauer, Manuela Sumyk, Catherine Birck, Vladimir Torbeev
Non-canonical [small alpha]-methyl amino acids were incorporated at various sites in the sequence of intrinsically disordered activation domain from the p160 transcriptional co-activator (ACTR) to facilitate the formation of [small alpha]-helical structures.
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