Filling the gaps in the genomic catalogue of melanoma subtypes

Melanoma is a neoplastic disorder that frequently arises on the sun-exposed skin of light-skinned individuals. Melanomas can also occur on anatomic sites that are partially or completely shielded from sunlight, and these subtypes affect world populations at similar incidences, independent of skin color. These sun-shielded melanomas also differ in their clinical and histologic presentations as well as in their patterns of driver mutations and mutational mechanisms. These notable differences have led to classifications distinguishing melanoma subtypes, originally based on clinical and histopathological features¹, and later integrating these features with genetic alterations².

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