Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing [Genetics]

Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA...

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