Kinetically Modulated Specificity against Single-base Mutants in Nucleic Acid Recycling Circuitry Using Destabilization Motif

Analyst, 2017, Accepted Manuscript
DOI: 10.1039/C6AN02731H, Paper

Tsz Wing Fan, I-Ming Hsing
Signal amplification in nucleic acid sensing improves detection sensitivity, but difficulties remain in sustaining specificity over time particularly under excess amount of single-base mutants. Here, we report a simple, self-refining...
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