Long-term volume reduction effects of endovascular embolization for intracranial meningioma: preliminary experience of 5 cases.

Long-term volume reduction effects of endovascular embolization for intracranial meningioma: preliminary experience of 5 cases.

World Neurosurg. 2017 Jun 14;:

Authors: Nakajima N, Fukuda H, Adachi H, Sasaki N, Yamaguchi M, Mitsuno Y, Kitagawa M, Horikawa F, Murao K, Yamada K

Abstract
BACKGROUND: Preoperative endovascular embolization of intracranial meningiomas denatures the tumor tissue, reduces intraoperative blood loss, and facilitates surgical removal. However, as most meningiomas are surgically removed within a few days after embolization, the effect of long-term volume reduction of the tumor due to the endovascular embolization remains unknown.
METHODS: Between January 2006 and December 2014, 5 patients with intracranial meningioma underwent endovascular embolization and were followed without surgical resection for >14 days. The reduction in tumor and peritumoral edema volumes on sequential head magnetic resonance imaging, along with the clinical symptoms, were retrospectively reviewed.
RESULTS: All the tumors indicated a 10-30% volume reduction 30 days after embolization, which continued thereafter; no meningioma regrowth was observed for >90 days in 2 of 5 cases. Moreover, the peritumoral edema volume was reduced by 30-70% at 30 days after embolization, and no subsequent increase was observed for >60 days in 4 of 5 cases. The neurological symptoms related to the tumor mass effect improved after embolization.
CONCLUSIONS: Endovascular embolization of intracranial meningiomas with n-butyl cyanoacrylate reduced the tumor and peritumoral edema volumes by 10-30% and 30-70%, respectively, within 30 days. Volume and edema reduction effect of embolization may last longer than expected, beyond the timing when most meningiomas are resected after embolization.

PMID: 28624563 [PubMed - as supplied by publisher]

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