Ampullary adenomas are rare neoplasms of the ampulla of Vater with an overall prevalence of 0.04% to 0.12% in autopsy series.1,2 They are increasingly recognized because of the widespread use of endoscopy and cross-sectional imaging and are often diagnosed in the context of screening of patients with familial adenomatous polyposis (FAP).1,3 Ampullary adenomas are premalignant lesions, with potential for malignant degeneration through the adenoma–carcinoma sequence.4 Therefore, resection has been advocated for sporadic adenomas and for select ampullary adenomas in patients with FAP.
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