Reproduction of the atopic march in an adult after allogeneic bone marrow transplantation from an atopic sibling

Allogeneic bone marrow transplantation (BMT) or hematopoietic stem cell transplantation is an established treatment for several hematologic disorders, such as severe aplastic anemia, leukemia, or severe combined immunodeficiency, among others. Transfer of specific IgE (sIgE)–mediated hypersensitivity after allogeneic BMT to a previously nonallergic recipient has been described.1,2 A prospective study found a long-term allergen sIgE-mediated hypersensitivity transferred during BMT.3 Another study found the appearance of a new allergen sIgE after BMT from atopic donors, suggesting that the atopic condition was transferred from the donor to the recipient.

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