Hypogammaglobulinemia E in 216 adults with IgG subclass deficiency and respiratory tract infections

Hypogammaglobulinemia E has been reported in 0.8% to 3.0% of adults unselected for disease associations.1,2 In persons with subnormal serum immunoglobulin (Ig) E, the prevalence of frequent or severe respiratory tract infections,3,4 other subnormal immunoglobulin isotypes,3,5 and autoimmune conditions3,4 was significantly greater than that in control subjects.3–5 To learn more, we performed a retrospective study to determine clinical and laboratory associations of hypogammaglobulinemia E (serum IgE <1 IU/L [<2.4 μg/L]) and IgE levels at diagnosis in 216 index adult patients with IgG subclass deficiency (IgGSD).

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