P332 Role of toll-like receptor signaling in epithelial barrier dysfunction in eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is a multifactorial, chronic, food-driven allergic disease characterized by epithelial barrier dysfunction and eosinophil-predominant allergic inflammation. Esophageal epithelial keratinocytes express functional Toll-like Receptors (TLR), but their role in disease pathogenesis is unclear. Recently, TLR2 and TLR3 have been identified as highly expressed on esophageal epithelium, and we have identified that TLR7 is differentially regulated by steroid and diet therapy for EoE.

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