Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma

Abstract

The role of HRAS mutations in the pathogenesis of various human cancers has been long established. Recent studies indicate that cutaneous nevi can also harbor HRAS, KRAS and NRAS mutations, and this group of RAS mutation positive birthmarks has been referred to as the mosaic RASopathies.¹

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