Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice [Immunology and Inflammation]

Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response, insulin content,...

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