Intraventricular glioblastoma multiforme in a child with L2-hydroxyglutaric aciduria.

Intraventricular glioblastoma multiforme in a child with L2-hydroxyglutaric aciduria.

World Neurosurg. 2017 Nov 25;:

Authors: Tan AP, Mankad K

Abstract
L2-hydroxyglutaric aciduria (L2-HGA) is a rare neurometabolic disease characterised by accumulation of L2-hydroxyglutarate (L2-HG), a potential oncometabolite resulting in significant lifetime risk for cerebral tumors. Here in, we present a case of intraventricular glioblastoma multiforme (GBM) in a 16-year-old child with L2-HGA who presented with rapid functional decline and persistent vomiting. The tumour was completely resected and the patient remained well at 2-year follow up. Clinicians should be aware of the usual insidious nature of the disease. Rapid deterioration is unusual and should raise the suspicion of tumour development. This case also illustrates the importance of surveillance neuroimaging in patients with L2-HGA. To the best our knowledge, only one case of GBM has been reported and it was sited in the temporal lobe, unlike the unusual intraventricular location in our case.

PMID: 29183865 [PubMed - as supplied by publisher]

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