Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis [Biochemistry]

Kinetochores are superprotein complexes that orchestrate chromosome segregation via a dynamic interaction with spindle microtubules. A physical connection between CENP-C and the Mis12–Ndc80–Knl1 (KMN) protein network is an important pathway that is used to assemble kinetochores on CENP-A nucleosomes. Multiple outer kinetochore components are phosphorylated by Aurora B kinase to...

http://ift.tt/2nQ93Zq