Reply to Liu et al.: Yin and yang of PTEN regulation [Biological Sciences]

In a letter to the editor, Liu et al. (1) find that PTEN contains some transcript variants that are polyadenylated and prematurely terminated in the first intron of PTEN. These transcripts are suggested to be 5′-UTR–containing promoter-spanning and to encode for three small RNAs (sRNAs), with one of these (sRNA3)...

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