Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance [Engineering]

Continuous BRAF inhibition of BRAF mutant melanomas triggers a series of cell state changes that lead to therapy resistance and escape from immune control before establishing acquired resistance genetically. We used genome-wide transcriptomics and single-cell phenotyping to explore the response kinetics to BRAF inhibition for a panel of patient-derived BRAFV600-mutant...

http://ift.tt/2zyJCwi