Structure-based prediction of ligand-protein interactions on a genome-wide scale [Biophysics and Computational Biology]

We report a template-based method, LT-scanner, which scans the human proteome using protein structural alignment to identify proteins that are likely to bind ligands that are present in experimentally determined complexes. A scoring function that rapidly accounts for binding site similarities between the template and the proteins being scanned is...

http://ift.tt/2BU51WR