IKK{alpha} inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting maȷor redox regulatory pathways [Pharmacology]

Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the CHUK locus,...

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