Characterization of drug-neutralizing antibodies in patients with Fabry disease during infusion

Publication date: Available online 5 February 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Malte Lenders, Boris Schmitz, Stefan Martin Brand, Dirk Foell, Eva Brand
In patients with Fabry disease, neutralizing anti-drug antibodies were identified as IgG4 isotypes. The determination of antibody titers during infusions indicated that high dosages of enzyme overcome anti-drug antibody titers, necessitating individually tailored dose adjustment.



http://ift.tt/2nOyS95