Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity [Immunology and Inflammation]

Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR). Here we explored the functional consequences of CAR-mediated signaling using a dual-specific CAR-T cell, where the same cell was triggered...

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