Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/{beta}-catenin pathway [Neuroscience]

Regulator of G protein signaling z1 (RGSz1), a member of the RGS family of proteins, is present in several networks expressing mu opioid receptors (MOPRs). By using genetic mouse models for global or brain region-targeted manipulations of RGSz1 expression, we demonstrated that the suppression of RGSz1 function increases the analgesic...

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