The ZBED6-IGF2 axis has a maȷor effect on growth of skeletal muscle and internal organs in placental mammals [Genetics]

A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is associated with increased muscle mass and reduced subcutaneous fat in domestic pigs. This mutation disrupts the binding of the ZBED6 transcription factor and leads to a threefold up-regulation of IGF2 expression in pig skeletal muscle....

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