Mast cell disorders: Protean manifestations and treatment responses

Mast cell disorders represent an emerging disease category notable for the diverse spectrum of presentations. Patients are clinically characterized by symptoms reflective of mast cell mediator release, which often includes episodes of urticaria with or without angioedema and flushing as well as episodes of recurrent potentially life-threatening anaphylaxis. Multiple systems can be targeted including cardiovascular, gastrointestinal (GI), psychiatric, respiratory and musculoskeletal. In addition, patients may have vague nonspecific complaints, such as abdominal discomfort or "brain fog".

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