Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates [Biophysics and Computational Biology]

Recent evidence has shown that, in addition to rigidity, the viscous response of the extracellular matrix (ECM) significantly affects the behavior and function of cells. However, the mechanism behind such mechanosensitivity toward viscoelasticity remains unclear. In this study, we systematically examined the dynamics of motor clutches (i.e., focal adhesions) formed...

http://ift.tt/2u2ESl3