Reply to Katsu and Baker: Using zebrafish PDX to screen drug sensitivity of endocrine-dependent cancers [Biological Sciences]

Katsu and Baker (1) highlight a potential weakness in using zebrafish patient-derived xenografts (zPDX) (2) for endocrine-dependent tumors. Katsu and Baker (1) report that, unlike human estrogen receptor (ER), progesterone may activate zebrafish mineralocorticoid receptor (MR) instead of inhibiting it (3). Treatment of zPDXs with progesterone would, therefore, possibly activate...

https://ift.tt/2GfwOCY