Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL [Cell Biology]

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and triggers the unfolded protein response (UPR). Failure to resolve ER stress leads to apoptotic cell death via a yet unclear mechanism. Here, we show that RNF183, a membrane-spanning RING finger protein, localizes to the ER and...

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