Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment [Immunology and Inflammation]

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T...

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