Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels [Biophysics and Computational Biology]

Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting arrhythmias and seizures. However,...

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