DNA methylation and transcriptome aberrations mediated by ER{alpha} in mouse seminal vesicles following developmental DES exposure [Cell Biology]

Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the reproductive tract of adult mice. Estrogen receptor alpha (ERα) plays a role in mediating these developmental effects. However, the developmental mechanism is not well known in male tissues. Here, we present...

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