DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity [Systems Biology]

An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity. Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies. Single-cell technologies are now available to guide effective drug combinations by accounting for...

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