From the pages of allergywatch July 2018

In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), type 2 inflammation and tissue eosinophilia suggest a poor prognosis, including increased postoperative recurrence risk. Recent studies have found that proton pump inhibitors (PPIs) can suppress production of the eosinophil chemoattractant eotaxin-3. The authors assessed the role of Th2 mediators in CRSwNP, along with the effects of eotaxtin 3 inhibition using PPIs.

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