Histomorphologic spectrum of germline-related and sporadic BAP-1 Inactivated Melanocytic Tumors

The histomorphology of BAP-1 inactivated melanocytic tumors (BIMTs) includes cases with spitzoid cytomorphology and cases with smaller epithelioid cells without spitzoid features. Approximately 12% of patients with BIMTs have germline BAP-1 mutations. BIMT patients with extensive junctional involvement of BAP-1 inactivated melanocytes, prior melanoma or BIMT may be considered for germline testing.

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