Insulin promoter in human pancreatic {beta} cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism [Cell Biology]

Both type 1 and type 2 diabetes involve a complex interplay between genetic, epigenetic, and environmental factors. Our laboratory has been interested in the physical interactions, in nuclei of human pancreatic β cells, between the insulin (INS) gene and other genes that are involved in insulin metabolism. We have identified,...

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