Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors [Applied Physical Sciences]

Cells in tissues undergo transdifferentiation programs when stimulated by specific mechanical and biochemical signals. While seminal studies have demonstrated that exogenous biochemical factors can reprogram somatic cells into pluripotent stem cells, the critical roles played by mechanical signals in such reprogramming process have not been well documented. In this paper,...

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