A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase [Medical Sciences]

The intravascular processing of triglyceride-rich lipoproteins depends on lipoprotein lipase (LPL) and GPIHBP1, a membrane protein of endothelial cells that binds LPL within the subendothelial spaces and shuttles it to the capillary lumen. In the absence of GPIHBP1, LPL remains mislocalized within the subendothelial spaces, causing severe hypertriglyceridemia (chylomicronemia). The...

https://ift.tt/2yJxXzo