Extant fold-switching proteins are widespread [Biophysics and Computational Biology]

A central tenet of biology is that globular proteins have a unique 3D structure under physiological conditions. Recent work has challenged this notion by demonstrating that some proteins switch folds, a process that involves remodeling of secondary structure in response to a few mutations (evolved fold switchers) or cellular stimuli...

https://ift.tt/2JsvsWl