On the role of sidechain size and charge in the aggregation of A{beta}42 with familial mutations [Biophysics and Computational Biology]

The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer's disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer's disease. Here we set out to explore how the physical properties of the altered side chains, including their sizes and charges,...

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