Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesions

ALK gene rearrangements have been described in spitzoid lesions with plexiform growth pattern., ALK alterations characterize a significant subset of Spitz nevi and atypical Spitz tumors and can coexist with BRAF gene mutations., ALK immunohistochemistry represents a simple and relatively inexpensive ancillary technique to classify lesions with ALK gene alterations.

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