Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated gastrointestinal food hypersensitivity characterized by profuse vomiting and diarrhea leading to dehydration and lethargy. FPIES typically presents in infancy and early childhood.1 Unlike IgE-mediated food allergy, symptoms have delayed onset, often occurring 1-4 hours after ingestion of the culprit food.2 Milk and soy are the most common triggers within the first three months of life. Solid food FPIES has a later onset than cow's milk and soy induced FPIES, likely due to the timing of introduction of solid foods.
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