Direct cell-cell contact activates SigM to express the ESX-4 secretion system in Mycobacterium smegmatis [Microbiology]

Conjugal cell–cell contact between strains of Mycobacterium smegmatis induces the esxUT transcript, which encodes the putative primary substrates of the ESAT-6 secretion system 4 (ESX-4) secretion system. This recipient response was required for conjugal transfer of chromosomal DNA from the donor strain. Here we show that the extracytoplasmic σ factor,...

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