Disrupting LXR{alpha} phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation [Medical Sciences]

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors (LXRs) are sterol-regulated transcription factors that play a central role in atherosclerosis by integrating cholesterol...

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