Specific-IgE to galactose-alpha-1,3-galactose (alpha-gal) has limited utility in diagnosing meat allergy in a tick-endemic population

Sensitization to galactose-alpha-1,3-galactose (alpha-gal) is considered a prerequisite to mammalian meat allergy (MMA), and can occur through tick bites, which is due to the paralysis tick, Ixodes holocyclus in Australia.1 The onset of symptoms is typically 3-6 hours following ingestion of mammalian meat, but immediate reactions are also described.2

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